The Ghana football association has refused to play their AFCON qualifier, which is scheduled for 25 March, in South Africa.
Media houses in Ghana reported that the association has written to CAF asking to play in a neutral venue.
GFA said this is because South Africa has a highly infectious strain.
South African and Ghana are tied at nine points at the top of Group C after four matches.
Other South African teams that have been denied entry into African countries include Celtic who were denied entry into Nigeria to play River’s FC. The match was eventually played in Benin on 23 January and Celtic lost 3-0.
Kaizer Chiefs have similarly been denied entry into Morocco this weekend where they were supposed to play Wydad.