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Seiphemo married a private person named Olga Ruberio in 2003 at The Royal Swazi Sun Hotel in Eswatini. They reportedly have three children together, a daughter named Katlego and two sons.
More recently, around 2020, reports emerged of a messy breakup between Seiphemo and his Generations: The Legacy co-star Zoe Mthiyane. Following this, it was reported that he had been in a relationship with Zandile Tshukulu, the granddaughter of Generations creator Mfundi Vundla, and that they had a baby together.
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In late September 2025, several South African news outlets and social media users posted about a new traditional wedding for Seiphemo. Videos and photos of the event were widely shared.
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