Loyiso MacDonald was born on the 7th of September 1986 in the Eastern Cape. He currently acts as Kagiso Khoza on Mzansi Magic telenovela the Queen.

Loyiso is married to a musician by the name Luphiwo. They got married on the 30th of September 2012 when he was 26 years old.

He studied Speech and Drama at Durban Film School and also worked with Durban Theatre for four years before relocating to Johannesburg.

Loyiso has appeared in Isibaya as Ntando Sibeko, Zabalaza, Intersexions season 2 and in plays ranging from drama to Shakespeare.

He revealed that he was s_exually abused while in Grade Six at the age of 12. He said a neighbor was in the habit of s_exually molesting young boys.

He is also a victim thus he told his parents about the incident and the other boys came forward after he had spoken up.